Two humans, George Struggs and Wade, are looking for a location in the Sonoran desert where they believe gold from the American Civil War has been buried. The story is told from the point of view of both a tarantula and a scorpion with both creatures often seeing the same thing but from a different perspective, both also being stalked by a rattlesnake.
Players can control a young male scorpion and an adult female tarantula and engage in brutal battles against other arachnids, insects, rats, and reptiles. The two creatures have different playing styles, with the scorpion's levels featuring more action-oriented gameplay, while the tarantula is more stealth-oriented, with less linear levels. The Wii Remote and Nunchuk are used for both movement and attacks, with motion controls incorporated for special attacks and finishing moves, while the tarantula also utilizes the pointer function to shoot webs. New abilities are also gained as the player progresses through the game.
Source: Wikipedia, "Deadly Creatures," available under the CC-BY-SA License.