In not too distant future a graveyard filled with dinosaur bones is found. A scientific breakthrough allows researchers, to restore the full DNA map of 30 different dinosaurs. In Dino Business players are investors building a dinosaur theme park on an island.
The island is divided by rivers into three parts, each part consists of nine or seven areas, that can hold one type of dinosaur. Only one part of the island is available at a time. The game has three phases, after each of which a scoring takes place. Each phase consists of a variable number of turns, until every area on the island part is occupied. Each turn begins by randomly setting up the market for the turn. On the market players take turns purchasing three different DNA that is coloured glass beads and dinosaur tiles, which show the type and amount of DNA needed to rescurrect the dinosaur. Anytime a player has everything he needs for resurrection he pays the DNA and places a dinosaur of his colour on an empty area.
Players score points for not only the dinosaurs they rescurrected, but also by having their dinosaurs on adjacent areas. The player with most points wins the game.