As a mad scientist you're tired of the world laughing at your devious and diabolical attempts to rule the world. So you're calling in a little help in making your doomsday machines that much more "doomier". Scientists of various disciplines are willing to help you out with your machine, but be cautious. Some scientists will sabotage your machine, making harder to finish - and some scientists are a bit thumb-fingered. Too many mistakes and the world will end a bit early, whether anyone wants it to or not.
Players collect scientists of various disciplines: biologists, volcanologists, chemists, engineers, and occultists work together to activate different machine components. As players take turns either drawing or assigning scientists, the Doommakers - scientists the bring about the apocalypse early - make critical mistakes. Too may mistakes, and the game ends, possibly without any completed machines.
When the game ends, the player with the most points wins. Players earn points through activating components, point bonuses on components, and point modifiers found on your original machine.