Semyaza, a former member of the Council of Heaven, steals pieces of God's wisdom and descends to Earth due to his love of humans. Alongside Azazel, Ezekiel, Armaros, Sariel, Arakiel and Baraqel−referred to as the Grigori−they accelerate human evolution and produce human-Grigori hybrids called Nephilim which threaten to destroy the world. Enoch, originally brought to Heaven as a scribe, is sent to Earth by God to recover the Grigori before Council of Heaven triggers a great flood to wipe out all life. After three centuries of searching, accompanied by the guardian angel Lucifel and four Archangels, Enoch discovers the Grigori's Tower in an isolated spacial realm.
Each of the levels uses a different artistic style and camera position, with levels alternating between 3D and 2D presentation. One level includes a driving sequence on a motorbike. During exploration and combat Enoch can jump, attack, block long and short-ranged attacks, and dodge. In combat, Enoch fights standard enemies and bosses in arenas, initially with his bare fists and then with three weapon types stolen from enemies. the weapons are the sword-like Arch, the long-range Gale, and the heavy-hitting Veil which also acts as a shield; each is strong or weak against another weapon. When in combat, Enoch's attacks are mapped to one button, with the frequency and timing of presses determining the type of attack; repeated presses launches a combination attack, which holding the button can trigger alternate strong attacks. Weapons must be periodically purified to recharge them as they lose attack power when used for a period of time. Enoch can also parry attacks or break an enemy's blocking stance with the right timing, allowing for counterattacks. During some later fights Enoch can trigger Overboost, which increases Enoch's attack power and unlocks unique skills.