Jesse Rentier is an agent of the Rentier Institute, a secret organization dedicated to battling supernatural creatures such as the Sanguisuge, vampires that prey on humanity. Working together with retired agent Edgar Gravenor, they follow the trail of Peter D'Abano, a high ranking vampire that advocates for declaring war on humanity before their technology develops to the point where it will become a threat to the Sanguisuge.
The player assumes control of Jesse Rentier, a vampire hunter. Jesse is equipped with several powerful firearms including a six-shot revolver, a lever-action rifle, and a flamethrower. He also has access to various melee attacks through a specialized gauntlet capable of accumulating electrical energy. Enemies can be stunned and staggered following a melee attack, allowing players to execute them using a special finisher move. Players can use the environment to their advantage. For instance, they can kick enemies into a spike trap, or shoot explosive barrels. Players will occasionally encounter boss characters, which are powerful enemies with unique attack patterns. As the player progresses, they will level up and gain skills and abilities.