Harley's Humongous Adventure (known in Japan as Kagakusha Harley no Haran Banjou 化学者ハリーの波乱万丈 which translates to: Harry the Chemist's Stormy Life) was originally developed by Visual Concepts, and funded by publisher Electronic Arts, but eventually published by Hi Tech Expressions.
The player controls Harley, a man in a green suit who shrunk himself to size of a bar of soap. The player's mission is to gather parts of Harley's (presumably) now destroyed shrinking machine to return him to normal size. As the player advances through levels, they pick items such as tacks, rubberbands and marbles. The many locations the player adventures through is Harley's lab where the initial incident occurs, Harley's Kitchen, Harley's toy room, where the player pilots a toy tank by himself, Harley's Bathroom, and other stages.
This is an old school 2D platform game. Enemies include flies, bees, ants, and the main boss is a deformed rat that tries to jump on the player, and after each encounter utilizes a household item for the limb he lost in the last encounter.
Visually, the game utilizes a mix of pixel art for the stage backgrounds, the menus and most objects, and digitized clay animation models for all characters. The clay animation was produced by A-OK Animation, who had also worked on Claymates, another Super Nintendo game featuring a somewhat similar graphical style.
The game was programmed, and designed in part, by Brian Greenstone of Pangea Software. This programmer previously wrote games for the Apple IIgs computer, which happens to share the same 65C816 microprocessor as the Super Nintendo.
Source: Wikipedia, "Harley's Humongous Adventure", available under the CC-BY-SA License.