From the back cover: "High Tech Enemies is the definitive sourcebook for high-tech villainy. This book is full of everything that every good Champions campaign needs: powered armor, robots, gadgets, androids, huge machines, cyborgs - the list goes on and on. Now your heroes can battle mutants that can mentally control electronics, match witch with mega-villains and their arsenal of devices and armies of agents, and encounter cyborgs from another world. What more oculd you possibly want?"
Approximately fourty characters are listed within, in six groups: the technophilic Cy-Force, the technophilic would-be world-conquerers Master Control, the brutes-for-hire The Destruction Company, the temporally-displaced Wormhole Gang, the renegade military H.A.W.C.S., an group of mutants with the ability to suppress or disrupt technology going by the name of the Anti-Tech League, and a small number of independent villians and antiheroes.