Noch mal! Deluxe uses the same gameplay as Noch mal!, which has also been published as Encore!.
On a turn, a player rolls the three color dice and three number dice, then chooses a color and number pairing that allows them to mark off an area on their personal player board. All other players then choose a color-number combination from the dice that remain. By filling all spaces in a column or of a color, you score bonus points.
Noch mal! Deluxe contains erasable player boards as well as a 3D dice tower that's set up inside the box bottom. What's more, Noch mal! Deluxe contains a co-operative variant played with the same rules in which players need to complete one of the five missions by game's end, whether color bonuses, completed rows, blocks of four, stars, or the spelling of "NOCHMAL". The game contains the original solo variant as well as a solo challenge using the new missions.