Nuclear Bro-liferation is a cooperative and competitive card game for 1-4 players. Players take the roles of Jon Johnson and his Special Operation Bros as they battle invading alien monsters. Along the way, players will face terrible social and political mishaps, friendly fire, and special boss monsters. Each game wave lasts 20-30 minutes, with up to four waves of increased difficulty. The competitive mode offers a cutthroat wave of resource grabbing, trophy hoarding, and backstabbing.
At the start of a players turn they will draw a card off the Battle Deck and either place the monster in the Battle Zone or resolve a political mishap. Next they can take one action to attack a monster, buy a item, heal, etc. After their action the player will draw one card from the Grunt Support deck to either aid or hinder the player on their turn. And finally, the monsters attack the player, causing 1 point of damage for every 4 strength. Then play moves to the next Bro.
The game continues until all monsters in the Battle Zone and Battle Deck are defeated. The players loose if all Bros die. If a Bro dies, you aren't out of the game yet! You can continue as a Bhrost and aid your team from the afterlife by drawing from the Battle Deck as normal and drawing 2 Grunt Support cards and choosing the better of the 2.
Competitive mode plays the same, however Bros will total up their kills at the end of the game, applying various modifiers.
The game can also be played solo! The player simply controls all 4 Bros at once, taking their turns one after another.
—description from the publisher