From the front page of the PDF:
For years the tenuous peace between Netheril and Cormyr held. For years the city of Urmlaspyr, last remnant of free Sembia, lay in between. Now something stirs in the darkest places of the city. Citizens run amok without apparent cause, wielding shadow powers they did not have before. What could cause these otherwise peaceful people to fly into a murderous frenzy? A Living Forgotten Realms adventure set in Urmlaspyr for characters of the Heroic tier (levels 1-10).
This adventure is part of Chapter 1 of the Desolation series. Chapter 1 includes four Heroic tier adventures leading up to the conclusion in CORE5-1. The other three parts are SPEC4-5, CORE4-4, and CORE4-5. You can play these four adventures in any order, but you should try to play them with the same character, and you should try to play all four parts before you play CORE5-1. The Desolation series also includes Paragon tier adventures (starting with SPEC4-6). It is not expected that a player can follow both tracks with the same PC.