Star Trek: Deep Space Nine: The Fallen is a third person shooter game, the third video game based on Star Trek: Deep Space Nine.
The story focuses primarily on the efforts of Starfleet to acquire the three orbs of the Pah-wraiths, which could potentially be used as powerful weapons of apocalyptic scale. In doing so, they are competing against the Cult of the Pah-wraiths, Prophet-following fanatics, a rogue Cardassian anti-Dominion group, and the Dominion itself.
The game can be played from the perspectives of Sisko, Kira or Worf.
The story is very loosely based on the trilogy of books, "Millenium", which involves 3 red orbs of prophecy which are said to create a red celestial temple when opened. It also includes a race from the books called the "Grigari" which come from the far end of the red wormhole.
Source: Wikipedia, "Star Trek: Deep Space Nine: The Fallen", available under the CC-BY-SA License.