In 2320, Jacob Lee and Max Barrow are contract freight transporters working for the United Jupiter Company (UJC). The two decide to retire after ferrying one last shipment between Europa and the UJC-operated Black Iron Prison on Callisto. Shortly after leaving Black Iron in their ship, the Charon, they are boarded by the Outer Way, a terrorist group purportedly responsible for a massive biological attack on Europa, and the ship crash-lands back on Callisto.
Health can be replenished with injectable packs found throughout levels. Jacob can use weapons to combat enemies, as well as a melee system to dodge enemy attacks while looking for openings to strike and kill them. Both combat styles can be mixed up, providing greater variety when facing enemy types. Jacob can collect and review audio logs during gameplay.