Toonstruck

Toonstruck is a 1996 point-and-click adventure game in which, although all the imagery is drawn and scanned into the game, the protagonist Drew Blanc (played and voiced by Christopher Lloyd) is an actual video-captured representation of the actor (the name is a pun, since the character has "drawn a blank" on coming up with a new idea for a character). Drew's sidekick, crudely named Flux Wildly, is a drawn character voiced by Dan Castellaneta. Toonstruck also features scan-line compressed FMV. It was also one of the first video games to include stock music from APM Music, notably the classic "Spooky Scherzo" by Sam Fonteyn.

Source: Wikipedia, Toonstruck , available under the CC-BY-SA License.