The evil Dr. Faryan and his army of bio-engineered monsters has taken over the colony known as Red Earth. One warrior though has gained the powers of a werewolf and challenges Dr. Faryan.
You start the game in human form, but by finding a Red W icon, the human is able to transform into a werewolf creature. The werewolf form offers higher jumps, quicker speed, greater strength, a shockwave attack, and the ability to climb walls. Also by collecting orbs you can became a super werewolf, increasing your strength, speed, and defense. Accidentally grabbing a blue W icon or losing too much energy will change you back into a human.
There are only 5 stages, but the game is infamous for its difficulty. it also came with a comic book.
Source: Wikipedia, "http://en.wikipedia.org/wiki/Werewolf:_The_Last_Warrior," available under the CC-BY-SA License.